A REVIEW ON FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET
Nishita Soni*, Dr. Dilip Agrawal, Ashok Kumar Sharma, Mohit Khandelwal and Dr. Rakesh Goyal
In this present scenario, the drug delivery system has become highly competitive and rapidly most evolving with ever increasing demand. Fast dissolving tablet (FDT) is such type of an innovative and unique drug delivery system which is intensly gaining much attention in the research field of rapid dissolving technology. Oral route is the most acceptable routes among all various routes for different patients of different age group because it is regarded as safest, convenient and economical route of administration. Therefore, recently many researcher and pharmaceutical companies developed fast dissolving tablet (FDT) by modifying the physio-chemical properties of drugs to their need with enhanced patient compliance and convenience. USFDA define FDTs to be the solid oral preparation that disintegrate rapidly in the buccal cavity with an in-vitro disintegration time of less than 30 seconds. FDTs improved patient compliance and also overcome the disadvantages of conventional dosage form especially dysphagia (difficulty in swallowing) in pediatric and geriatric patients. FDT formulations have the advantage over the both conventional tablet formulation as well as liquid dosage form. There are several methodologies that are conventional or patented based o spray drying, sublimation, melt granulation, direct compression, freeze drying/lyophilization, mass extrusion, etc. have been developed for manufacturing of FDTs. This review includes the requirements, advantages, limitations, various technologies developed for FDT, evaluation methods of fast dissolving tablets.
Keywords: Fast dissolving tablets (FDT), Super disintegrants, Dysphagia,, Bioavailability, Evaluation.
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