TRANSFEROSOMES: A TRANSDERMAL APPROACH FOR BCS III AND BCS IV DRUGS

Ayesha Bin Sayeed Sharfi* and Dr. Abdul Mannan

ABSTRACT

In today's drug development world, combinatorial chemistry, high-throughput screening, and genomics have provided a technologic platform that produces a large number of new chemical entities with therapeutic potential each year. Its outcome the new chemical entities shifted towards higher molecular weight, low lipophilicity and poor aqueous solubility which primarily affects the bioavailability of drugs. Hence, the poor aqueous solubility not only limits the drug's biological application but also challenges its pharmaceutical development. Novel drug delivery systems are now a days is creating a new interest in development of drug deliveries. TDDS is the permeability of the skin, it is permeable to small molecules, lipophilic drug and highly impermeable to the macromolecules and hydrophilic drugs. .This review highlights the significant solubility problem and BCS formulation choices, and importance of Transferosomes. Also, this review summarizes the role of lipids in the enhancement of bioavailability, Mechanism of Transferosomes and BCS class III and IV drugs as an ideal candidate for the transferosomes formulation with their significant finding in research. Based on the available data, the Transferosomes makes this drug delivery systems as one of the promising delivery systems and will be a solution to the formulation scientist.

Keywords: BCS, Transferosomes, Solubility, Lipophilicity.