EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

CA15-3 IN PREDICTING AXILLARY LYMPH NODE METASTASIS IN BREAST CANCER

Dr. Md. Sidur Rahman Mollah*, Dr. Md. Abdul Quiyum, Dr. Niazur Rahman Molla, Dr. Md. Latiful Bari, Dr. Md. Amjad Hossain and Dr. Samia Mostary

ABSTRACT

Introduction: Breast cancer is one of the most common cancers worldwide. A number of marker available among them CA15-3 levels provide useful information for diagnosis, treatment, assessing prognosis, the early detection of disease progression in breast cancer. Some author described rise of Ca 15-3 also associated with axillary lymph node metastasis. This was not established in our country. Objectives: Utility of CA15-3 in predicting metastasis of breast cancer to axillary lymph node. Methods: A cross sectional study was performed among 60 patients who underwent mastectomy with axillary dissection. Association seen between preoperative elevated CA 15-3 with histologically proven axillary lymph node metastasis postoperatively. Results- Majority (88.3%) patients are within normal CA15-3 level but only 11.7% patients showed raised CA15-3 level preoperatively among breast cancer patient. Mean ± SD (Min-Max) were 20.92 ± 20.38 (0.19-150.8) Those who have axillary lymph node positive, only 7 (13.2%) patients showed raised CA15-3 level but remaining 53 (86.8 %) patients showed normal CA15-3 level (statistically insignificant, p<0.584). Validity test of CA15-3 shows sensitivity, specificity, PPV, NPV and accuracy were 24.5%, 100%, 100%, 14.9% and 33.3% respectively. Conclusion: in our study, we found that raised CA15-3 level did not show significant association with lymph node metastasis in breast cancer.

Keywords: Breast cancer, CA 15-3, Axillary lymph node metastasis.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia