EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

LAST FIVE YEARS’ LABORATORY BASED STUDIES TO ADDRESS ACETAMINOPHEN INDUCED HEPATOTOXICITY

Abdullah Al Mahmud Ashik and Mohammad Borhan Uddin*

ABSTRACT

Acetaminophen is a commonly used analgesic drug that is considered an over-the-counter drug. Chronic use of this analgesic drug, as well as overdose, can cause hepatotoxicity. Acetaminophen metabolism takes place within liver. Hepatotoxicity from this drug is caused by the development of the poisonous NAPQI metabolite, as well as glutathione (GSH) depletion, oxidative stress, and mitochondrial dysfunction, all of which lead to a decrease in adenosine triphosphate (ATP) storage. There are so many other factors that are responsible for acetaminophen-induced hepatotoxicity. Many studies have recently been conducted in order to establish therapeutic options by designing a new medicine to improve acetaminophen toxicity. Many investigations have been conducted in the laboratory to determine the hemodynamic effects and in several studies drugs were given intraperitoneal. The herbal medicine was also used by the researchers to significantly reduce acetaminophen toxicity. They derived a variety of natural compounds from various plants and used these items in their research. There have been numerous studies conducted in order to discover a better alternative antidote. These experiments focused on a variety of molecules, including Nrf2, c-Met, thrombospondin-1, CYP2E1, and others. These were proved only in the lab-based animal trial. In future, preclinical trials are required to better determine the safety and efficacy of these compounds.

Keywords: Hepatotoxicity, Acetaminophen, Intraperitoneal, herbal compound, antidote, NAPQI, Glutathione hormone.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia