EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF CAPSULES CONTAINING PHYYTOSOMES OF PHYSALIS MINIMA LINN. FOR IMPROVED THERAPEUTIC OUTCOME

Nilakshi G. Mahakalkar*, Neelam Dighe and Dr. Jasmine G. Avari

ABSTRACT

Herbal drug having some limitation over oral drug delivery which includes poor solubility, permeation and bioavailability so as to improve these parameters of herbal novel drug delivery system known as phytosome is used. By applying this novel approach bioavailability is increased. The objective of the current project is to develop a herbal capsules loaded with phytosomes with a systematic approach to yield better products stability and it can be easily administered with oral drug delivery. It can improved acceptability and therapeutic potential owing to its greater bioavailability. Different phytosomal complexes of Physalis minima extracts containing a molar ratio of 1:1, 1:2, 1:4 using methanolic extract and soya lecithin were prepared by solvent evaporatiion technique. Physalis minima phytosomes were characterized by particle size, zeta potential, entrapment efficiency, Fourier transform infrared spectroscopy and in-vitro drug release. Prepared phytosomes showed 51 % entrapment efficiency, particle size (254nm), zeta potential (-7.57) and field emission scanning electron microscopy (FE-SEM) show spherical shaped particles. Physalis minima phytosome loaded capsule showed the capsules weight variation within the limit, disintegration time 10-13 min and in-vitro drug release of 93%. The drug content was found to be in the range of 69-83 % in all formulations.

Keywords: Phytosomes, novel drug delivery, entrapment efficiency.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )