THE CLINICAL CORRELATION OF PRO-INFLAMMATORY AND ANTI-INFLAMMATORY BIOMARKERS WITH TISSUE REGENERATION: A META-ANALYSIS

Amit Gupta*, Himanshi Verma, Deepak Chandra Joshi, Pranav Sharma, Pankaj Yadav, Veeresh Kumar Rathour and Chandra Pratap Singh

ABSTRACT

To monitor inflammation in a useful way, the markers utilized must be valid: they must reflect the inflammatory process under inquiry and they must be predictive of future health state. In 2019 the Nutrition and Immunity Task Force of the International Life Sciences Institute, European Branch, organized an expert group to attempt to identify robust and predictive markers, or patterns or clusters of markers, which can be used to assess inflammation in human nutrition studies in the general population. Inflammation is a normal process and there are a number of cells and mediators involved. These markers are involved in, or are formed as a result of, the inflammatory process irrespective of its cause and its location and are common to all inflammatory conditions. Currently, there is no consensus as to which indicators of inflammation best identify low-grade inflammation or differentiate between acute and chronic inflammation or between the numerous phases of inflammatory reactions. There are a variety of modifying factors that vary the concentration of an inflammatory marker at a given period, including age, diet and body fatness, among others. Measuring the concentration of inflammatory markers in the bloodstream under basal conditions is probably less informative compared with data relating to the concentration change in response to a challenge.

Keywords: Inflammatory, AD progression, phagocytosis, adipocyte.