EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE PATTERN OF BICARBONATE LEVEL IN PATIENTS ON MAINTENANCE HAEMODIALYSIS AND IT'S CORRELATION WITH FREQUENCY OF DIALYSIS AND POTASSIUM LEVEL

Anchana Raj, Anusree V. S., Gokul Krishna A., Padmesh P. R., E. Sam Jeeva Kumar, Ranjani Ravi*, Prasobh G. R.

ABSTRACT

Background: Chronic kidney disease (CKD) describes the gradual loss of kidney function. Metabolic acidosis can be defined as the pathological condition characterized by an absolute or relative increase in body concentration of hydrogen ions with a reduction in serum bicarbonate. One of the most important function of the kidney is the maintenance of acid base balance. Loss of renal function happens progressively leading to loss of excretory, metabolic and endocrine functions. Aim: To study the pattern of bicarbonate level in patients on maintenance haemodialysis and correlation with frequency of dialysis and potassium level. Objective: To determine the pattern of bicarbonate level in patients on maintenance haemodialysis To find the correlation with frequency of dialysis and potassium levels. To find the correlation with bicarbonate and potassium levels. Materials And Methods: This prospective observational study was carried out in 36 patients undergoing maintenance haemodialysis. In our study,26 patients were on twice weekly dialysis and 10 patients were on thrice weekly dialysis. The study was conducted in patients age greater than 18 years old and bicarbonate level <22mEq/l. Health related quality of life in patients undergoing maintenance haemodialysis were assessed by using KDQOL questionnaire. As a counseling aid Patient Information Leaflet were provided. A written informed consent form was obtained. Result And Discussion: This study aim is to determine the pattern of bicarbonate levels in patients on maintenance haemodialysis and it's correlation with frequency of dialysis and potassium level. Quality of life was assessed using KDQOL SF-36 scale and to evaluate the impact of patient counseling on improving the quality of life in patients with End stage renal disease. From the study,there was an increase in quality of life in patients who followed all the recommended dietary modifications and followed all the follow up of dialysis regularly. There was a significant change in bicarbonate level among patients on haemodialysis at successive follow up. There was no significant difference in the variations in bicarbonate level according to frequency of dialysis. There is a correlation between bicarbonate and potassium level as serum bicarbonate level increases and serum potassium decreases and also patients have significant increase in quality of life after patient counseling. Conclusion: There was a significant change in bicarbonate level in successive follow up. There was no significant difference in the variations in bicarbonate level according to frequency of dialysis. It was clear that potassium level at 6th follow up was found to be balanced under the criteria of KDQOL and also the bicarbonate level was increased (≥22mEq/l) from the KDQOL. Thus we concluded that there is a correlation between bicarbonate and potassium level as serum bicarbonate level increases, serum potassium level decreases. There is a significant improvement in quality of life in patients whom bicarbonate levels improved after patient counseling.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )