EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PROSPECTIVE ANALYTICAL OBSERVATIONAL STUDY OF HAEMODYNAMIC STABILITY OF INJECTION ETOMIDATE AND INJECTION PROPOFOL FOR INDUCTION OF GENERAL ANAESTHESIA IN ELECTIVE SURGERIES

Dr. Nida Shaikh, Dr. Prakash Dhumal and *Dr. Anushree Chaudhari

ABSTRACT

Introduction: Etomidate produces dependable, fast onset of anaesthesia and is perceived as having a favourable haemodynamic profile, making it a commonplace preference for patients vulnerable to hypotension, or wherein hypotension is undesirable. This study was conducted to evaluate the effect of injection Etomidate and injection Propofol on haemodynamics during and after induction of general anaesthesia. Methods: After taking approval from institutional ethics committee and written informed consent from all patients, 70 ASA I-II class patients, 18-85 years old, both male and female posted for elective surgeries were included in the study. Standard noninvasive monitors were attached. Inj glycopyrolate 4mcg/kg iv, inj midazolam 0.02mg/kg iv and inj pantazocine 0.3mg/kg iv. were given. Preoxygenation was done for 3 min and patients were randomly divided into group E induced with injection Etomidate(0.3mg/kg) iv and group P induced with injection Propofol (2mg/kg) iv. After loss of eyelash reflex, inj succinylcholine 1.5mg/kg was given iv and intubation done after 60 secs. Heart rate(HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP) were recorded at baseline, 0min(intubation), 1min, 2min, 3min, 5min, and 10min and changes were compared in both the groups. Percentage increase or decrease was calculated by (Baseline value – Values at specific intervals)*100/ Baseline value.Chi-square test was used as test of significance for qualitative data.Independent t test was used as test of significance for quantitative variables. P value of <0.05 was considered as statistically significant. Results: The mean HR, percentage increase of HR was significantly higher in group P from 0-10min. The mean SBP, DBP and MAP were significantly lower in P at 5 to 10 min, 3 to 10min and 3 to10 min after intubation respectively and the mean percentage change in SBP, DBP and MAP was significantly lower in P from 3 to 10 min, 2 to 10min and 2 to 10 min respectively indicating significant hypotension in this group. Conclusion: Injection Propofol at 2mg/kg iv caused significant hypotension and tachycardia as compared to 0.3mg/kg iv of inj Etomidate making Etomidate the better choice as compared to propofol for induction of general anaesthesia in terms of hemodynamic stability.

Keywords: etomidate, induction agent, hemodynamic stability.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: DECEMBER ISSUE PUBLISHED

    DECEMBER Issue has been successfully launched on 1 December 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )