EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

GENOTOXIC EFFECT OF ARSENIC ON CHROMOSOME STRUCTURE OF MICE

Ranjit Kumar*, Vibha Gahlot, Md Ali, Seemab Akhtar and Arun Kumar

ABSTRACT

Arsenic toxicity has become a global public health concern and has affected human health adversely in many different ways. Exposure to inorganic arsenic occurs via environmental and occupational exposures. The people residing in arsenic hit area were prone to different types of disease including skin disease, reproductive disease and cancer. Children of these areas have symptoms of severe arsenicosis and low memory status. The present study is designed to study the genotoxic effects of arsenic on chromosome structure of Swiss albino mice. The control group of 6 mice received distilled water as drinking water. The ‘treatment’ group received sodium arsenate 6 mg/kg body weight /day by Gavage method for 16 weeks. Mice were sacrificed and bone marrow was removed for chromosomal study. At twelve weeks administration of arsenic elongation of chromosomal arm, decrease in size of centromeres and Increase in thickness of chromosomal arm were observed. Elongated thin arm of chromosomes were observed. Less dense telomeres were also observed. At sixteen weeks administration of arsenic, serrated outer surface of chromosomes were observed. Centromeres were not distinct with clustered chromatid and fragmented arms of sub metacentric chromosomes were observed. It is concluded from the study that long term arsenic exposure causes chromosomal anomalies through heterogenous structure, elongation and finally fragmentation of chromosomes. The study on Swiss albino mice with arsenic did confirm the genotoxic effect of arsenic through chromosomal assay.

Keywords: Centromere; Telomere; Metacentric; Heterogenous; Arsenicosis.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )