EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

THE IMPLICATION OF SERUM CALCIUM-PHOSPHORUS RATIO TO ASSESS RHEUMATOID ARTHRITIS (RA) IN WOMEN OF TRIPURA, A NORTH-EASTERN STATE OF INDIA

Shukdeb Acharjee M.Sc, Avik Sarkar Ph.D, Chandan Raybarman M.D, Chinmoy Ghosh Ph.D, and
Surajit Bhattacharjee Ph.D*

ABSTRACT

Background: Systemic inflammation during rheumatoid arthritis (RA) affects multiple organs and metabolic pathways. Interleukin-18 (IL-18) and tumour necrosis factor-alpha (TNF-α) are the novel cytokines in RA, which mediate synovial inflammation and articular manifestations through the modulation of osteoprotegerin (OPG) and receptor activator of nuclear factor-kappa β Ligand (RANKL) expression. This might be reflected into serum calcium to phosphorus ratio (Ca/P) of RA patients. In this context, our present study investigates the role of serum Ca/P in the assessment of systemic inflammation in treatment-naive RA patients. Methods: This cross-sectional study (2017-2019), conducted at Tripura, India, included 146 RA women (duration ≤15 months) and 40 age and gender-matched healthy control (HC). All participants were divided into pre-menopausal (PreM) and post-menopausal (PostM) group. We measured serum Ca, P, IL-18, TNF-α, OPG, and RANKL in all patients and HC. Pearson’s bivariate correlation(r) and partial correlation (pR) analysis were performed to correlate Ca/P with IL-18, TNF-α and OPG to RANKL ratio (OPG/RANKL). Results: Serum Ca/P was found to be negatively correlated with IL-18 (PreM, r=-0.68, p=0.01; pR=-0.54, p=0.01 and PostM, r=-0.53, p=0.01; pR=-0.66, p=0.01) and TNF-α (PreM, r=-0.56, p=0.01; pR=-0.45, p=0.01 and PostM, r=-0.66, p=0.01; pR=-0.51, p=0.01). On contrary, significant positive correlation was observed between Ca/P and OPG/RANKL (PreM, r=-0.81, p=0.01; pR=-0.73, p=0.01 and PostM, r=-0.77, p=0.01; pR=-0.68, p=0.01). Conclusions: The study highlights a strong association between Ca/P and systemic inflammation in RA. This implicates that Ca/P could be used as a marker for the real-time evaluation of RA.

Keywords: Ca/P; cytokines; OPG/RANKL; Osteoprotegerin; Rheumatoid Arthritis.

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