EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE IMPLICATION OF SERUM CALCIUM-PHOSPHORUS RATIO TO ASSESS RHEUMATOID ARTHRITIS (RA) IN WOMEN OF TRIPURA, A NORTH-EASTERN STATE OF INDIA

Shukdeb Acharjee M.Sc, Avik Sarkar Ph.D, Chandan Raybarman M.D, Chinmoy Ghosh Ph.D, and
Surajit Bhattacharjee Ph.D*

ABSTRACT

Background: Systemic inflammation during rheumatoid arthritis (RA) affects multiple organs and metabolic pathways. Interleukin-18 (IL-18) and tumour necrosis factor-alpha (TNF-α) are the novel cytokines in RA, which mediate synovial inflammation and articular manifestations through the modulation of osteoprotegerin (OPG) and receptor activator of nuclear factor-kappa β Ligand (RANKL) expression. This might be reflected into serum calcium to phosphorus ratio (Ca/P) of RA patients. In this context, our present study investigates the role of serum Ca/P in the assessment of systemic inflammation in treatment-naive RA patients. Methods: This cross-sectional study (2017-2019), conducted at Tripura, India, included 146 RA women (duration ≤15 months) and 40 age and gender-matched healthy control (HC). All participants were divided into pre-menopausal (PreM) and post-menopausal (PostM) group. We measured serum Ca, P, IL-18, TNF-α, OPG, and RANKL in all patients and HC. Pearson’s bivariate correlation(r) and partial correlation (pR) analysis were performed to correlate Ca/P with IL-18, TNF-α and OPG to RANKL ratio (OPG/RANKL). Results: Serum Ca/P was found to be negatively correlated with IL-18 (PreM, r=-0.68, p=0.01; pR=-0.54, p=0.01 and PostM, r=-0.53, p=0.01; pR=-0.66, p=0.01) and TNF-α (PreM, r=-0.56, p=0.01; pR=-0.45, p=0.01 and PostM, r=-0.66, p=0.01; pR=-0.51, p=0.01). On contrary, significant positive correlation was observed between Ca/P and OPG/RANKL (PreM, r=-0.81, p=0.01; pR=-0.73, p=0.01 and PostM, r=-0.77, p=0.01; pR=-0.68, p=0.01). Conclusions: The study highlights a strong association between Ca/P and systemic inflammation in RA. This implicates that Ca/P could be used as a marker for the real-time evaluation of RA.

Keywords: Ca/P; cytokines; OPG/RANKL; Osteoprotegerin; Rheumatoid Arthritis.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )