ORGANOGEL: A NEW APPROACH IN TOPICAL DRUG DELIVERY SYSTEM
Chetan Sharma*, Dr. Dilip Agrawal, Dr. Rakesh Goyal, Ashok Kumar Sharma and Mohit Khandelwal
The topical routes, like ophthalmic, rectal, vaginal and skin offer certain visible advantages for drug delivery like direct application of drug to the location of action and persistence of action for prolonged periods of your time. Skin is one among the foremost readily accessible and main route for topical drug delivery. Gels represent semisolid dosage forms, intended for skin application or to some mucosal surfaces either for local action or for emollient properties. Gel is preferred for topical application because of more stability and better application property. The main objective of this article is to review all the knowledge associated with gels like structure, properties, characteristics, classification, uses, polymers, formulation, evaluation and future scope of gels. Organogels are semi-solid systems, during which an organic liquid part is immobilized by a three-dimensional network composed of self-assembled, intertwined gelator fibers. Despite their majoritarily liquid composition, these systems demonstrate the looks and rheologic behaviour of solids. Investigatory analysis relating these systems has only picked up speed within the previous few decades. Consequently, several burning queries regarding organogel systems, like the specific molecular needs guaranteeing gelation, still expect definite answers. nonetheless, the application of various organogel systems to varied areas of interest has been fast to follow their discoveries. Unfortunately, their use in drug delivery continues to be quite limited by the scarce toxicology data on the market on organogelators, as well as by the few pharmaceutically-accepted solvents utilized in gel systems. This review aims at providing a worldwide view of organogels, with special emphasis on the interaction between the gelator's structural characteristics and therefore the succeeding intermolecular interactions. A consequent focus is placed on the applying of organogels as drug delivery platforms for active agent administration via various routes like transdermal, oral, and parenteral.
Keywords: Gel transition temperature, Organogel, Organogelator, Skin, Topical drug delivery Topical, Gel, Bigel, Hydrogel, Skin, Spreadability, Permeation.
[Full Text Article]