EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PHARMACOLOGICAL ASSESSMENT OF ARJUNA GHRITA FORMULATIONS FOR MOOTRASANGRAHNIYA (ANTI-DIURETIC) ACTIVITY IN RATS

Hetal Aghera*, Vishva Savaliya, Maulik Ghetia, Mukesh Nariya, Vinay Shukla and
Pradeepkumar Prajapati

ABSTRACT

The formulations of Terminalia arjuna Roxb. Arn. & Wt. bark are highly recommended for cardiac patients. In classics Arjuna is also reported as mutrasangrahniya (Anti-diuretic). However, other properties and uses of Arjuna are not well-known. Therefore, the present study is aimed to assess anti-diuretic activity of Arjuna ghrita on acute and long-term administration in rats to support the traditional claim made on Arjuna. In acute study, the test formulations were administered once while in chronic study test formulations were administered for 7 consecutive days. Furesemide (10 mg/kg/day) was used as reference standard drug. Total urine volume at 6 and 24 hrs, pH, specific gravity and electrolytes excretions were evaluated in acute and chronic phase of study. The results revealed that there was decease in urine volume, pH, and specific gravity and significantly diminish electrolyte excretions in Arjuna ghrita treatment, which is totally reversal to furesemide, a standard diuretic drug denoted that Arjuna ghrita (4.3g/kg, po) was act as anti-diuretic or urinary astringent in albino rats and may be useful in the clinical conditions of nocturia.

Keywords: Terminalia arjuna Roxb. Arn. & Wt. Arjuna ghrita, Urinary astringent, Furesemide, Anti-Diuretic activity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )