EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EXPRESSION OF P16 PROTEIN IN SURFACE EPITHELIAL OVARIAN CARCINOMA & ITS ASSOCIATION WITH HISTOPATHOLOGICAL GRADING

Dr. Syeda Nabila Islam Juthee*, Dr. Mohammad Zillur Rahman, Dr. M Shahab Uddin Aahmad,
Dr. Sharmin Ashraf Rima, Dr. Purabi Sarkar and Dr. Rumana Mahmud

ABSTRACT

Background: Malignant ovarian tumors are the seventh most common female cancer and one of the leading causes of morbidity & mortality. In Bangladesh, ovarian cancer ranks as the 4th most prevalent cancer. Surface epithelial ovarian carcinomas are the most common malignancy of ovary which constitute more than 90%. Prognosis and treatment protocol for ovarian carcinomas are depend on histopathological grade. p16 is a tumor suppressor gene which is a negative cell cycle regulator. Several studies have linked the role of p16 protein in ovarian tumorigenesis. In ovarian carcinoma p16 is either deleted, downregulated, or overexpressed. p16 is overexpressed in high grade epithelial ovarian carcinoma in comparison to low grade carcinoma. Expression of p16 is directly proportional to grading of the tumor and which could be a potential target for therapy. Keeping this on mind we aimed to investigate the immunohistochemical expression of p16 in ovarian carcinoma and to assess its association with tumor grade. Materials and Methods: This cross-sectional study was conducted in the Department of Pathology, Chittagong Medical College, Chattogram from March 2019 to February 2021. Forty-five Haematoxylin and Eosin stained slides of ovarian carcinoma cases were evaluated to find out their histopathological type, grade. Immunostaining was done by using primary antibody against p16 (Rabbit monoclonal, dilution 1:100). Patient’s demographic data were collected and recorded in a predesigned data sheet. Statistical analysis was carried out as required. Ethical practice was ensured in every step of the study. Results: Among the 45 cases, the age range were 20-67 years (mean age was 46.42 years; SD 11.80). Majority of the tumors (n = 23, 51.11%) were diagnosed as serous carcinomas, 12 (26.67%) cases were diagnosed as endometrioid carcinomas, 10 (22.22 %) cases were diagnosed as mucinous cystadenocarcinomas. Seventeen (37.8%) cases were low grade and twenty-eight (62.3%) cases were high grade. Among the 23 serous carcinomas ,14 cases were high grade and 9 cases were low grade. Ten cases were diagnosed as mucinous cystadenocarcinomas and out of the them two cases were low grade and eight cases were high grade carcinoma. In case of endometrioid carcinomas, six cases were low grade and six cases were high grade. p16 score among 45 patients, 11 (24.4%) cases were negative and 34 (75.6%) cases were positive. Statistically significant association was found between tumor grades and p16 expression (p<0.05). Conclusion: This study found statistically significant association between histopathological grade and p16 expression (p<0.05). These findings may be helpful for selecting appropriate therapy for ovarian carcinoma patients.

Keywords: Malignant ovarian, malignancy, carcinoma patients, serous carcinomas, p16.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )