SYNTHESIS AND EVALUATION OF ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY OF THIOSEMICARBAZONE DERIVATIVES
Manisha Arora*, Ravi Kumar Dhawan, Bhargvi Sharma, Navroop Kaur, Prince Ahad Mir, Jasreen Uppal, Navneet Nagpal
Background: The threat of antimicrobial resistance has never been more acute, and the need for answers has never been greater. This work aimed to synthesize and evaluate the antimicrobial activity and antioxidant activity of novel thiosemicarbazones. Method: Seven novel thiosemicarbazone derivatives were synthesized using 4-methyl-3-thiosemicarbazide as the main reactant and different aromatic aldehydes by a base-catalyzed nucleophilic addition reaction followed by a condensation reaction. Reactions were monitored using the thin-layer chromatography technique and the newly synthesized derivatives were characterized by UV-Visible, FTIR, and NMR spectroscopy. Prepared derivatives were screened for anti-microbial and anti-oxidant activity. Results: The proposed route for synthesis gave high to moderate yields of Thiosemicarbazone derivatives and showed promising antifungal, antibacterial, and antioxidant activity. Conclusion: These findings suggested that prepared compounds were showed promising antifungal and antibacterial activities and can be used as scaffolds to design new antimicrobial drugs.
Keywords: Anti-fungal, anti-bacterial, anti-oxidant, thiosemicarbazones.
[Full Text Article]