MAST CELL STABILIZATION ACTIVITY OF ROOTS OF BHARANGI (CLERODENDRU SERRATUM L MOON) AND LEAVES OF AGERATUM CONYZOIDES L. AN INVITRO STUDY

*Dr. Kavana K. S., Dr. Manasa R. and Dr. Veena M. S.

ABSTRACT

A mast cell is a type white blood cell. Specifically it is a type of granulocyte derived from the myeloid stem cell which is a part of the immune system and neuro immune systems and contains many granules rich in histamine and Heparin. Mast cells are involved in the manifestation of various disorders such as parasitic infections, mast cell activation disorders, allergic disorders, anaphylaxis, autoimmunity, Mastocytosis, clonal disorders etc.[1] Mast cell stabilizers are common medications used to prevent or control certain allergic disorders. They block a calcium channel essential for mast cell degranulation, stabilizing the cell and thereby Preventing the release of histamine and related mediators. Rat mesenteric bits are stored at laboratory in aseptic precautions, stock solutions to be prepared test samples to be prepared at different concentrations. Of aqueous and alcoholic extracts of Bharangi moola and leaves of Agreatum conyzoids. In this study number of intact mast cells, number of degranulated cells, percentage of stabilization is observed.[2]

Keywords: Bharangi moola, Ageratum conyzoides, leaves, mast cell, invitro, mast cells.