EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

AN OBSERVATIONAL STUDY ON EFFICACY AND SIDE EFFECTS OF PPI, DOXYCYCLINE, BISMUTH SUBSALICYLATE AND NITROIMIDAZOLE IN BISMUTH QUADRUPLE THERAPY OF H.PYLORI GASTRITIS PATIENTS - A PILOT STUDY

Farhanban S. H., Lakshmi Krishna, Sumayya A. R., Meenu A. P., Soumya R. V.*, Dr. Prasobh G. R.

ABSTRACT

Background:- Helicobacter pylori (H.pylori) is a type of bacteria that causes infection in the stomach. It is the main cause of peptic ulcers, and it can also cause gastritis and stomach cancer. Tests and procedures for diagnosis of H.pylori include blood test, especially Rapid Urease Test(RUT positive).Bismuth quadruple therapy (BQT), consisting of a proton pump inhibitor(PPI), Bismuth and two antibiotics (Doxycycline and Nitroimidazole) has been recommended in most current H.pylori treatment guidelines as a first line regimen. Method:-This is a Prospective Observational Study carried out in 20 patients.In this study, we assess the symptomatic improvement caused by Bismuth regimen therapy in H.pylori gastritis patients. The H.pylori patients were given Bismuth subsalicylate, PPI, Doxycycline and Nitroimidazole. The primary endpoint of this study was to evaluate the efficacy and side effects of Bismuth quadruple therapy. The efficacy will be assessed using GSRS(Gastrointestinal symptoms rating scale) and side effects by questionnaire. Result:- A total of 20 patients with H.Pylori gastritis fulfilling the study criteria were selected. Bismuth quadruple therapy was given for all patients and their symptomatic improvement and side effects were assessed. Almost all the patients found to relieve symptoms. Most subjects experienced some minor side effects during the course of therapy. There was no mortality or major morbidity recorded in the study. It was observed that bismuth quadruple therapy have maximal beneficial effect for H.Pylori gastritis patients. Conclusion:- From this study, it was concluded that Bismuth Quadruple therapy consisting of PPI, Doxycycline, Bismuth subsalicylate and Nitroimidazole has more efficacy with minimal side effects seems to be better treatment option.

Keywords: .


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 October 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: OCTOBER ISSUE PUBLISHED

    OCTOBER Issue has been successfully launched on 1 October 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )