AN OBSERVATIONAL STUDY ON EFFICACY AND SIDE EFFECTS OF PPI, DOXYCYCLINE, BISMUTH SUBSALICYLATE AND NITROIMIDAZOLE IN BISMUTH QUADRUPLE THERAPY OF H.PYLORI GASTRITIS PATIENTS - A PILOT STUDY
Farhanban S. H., Lakshmi Krishna, Sumayya A. R., Meenu A. P., Soumya R. V.*, Dr. Prasobh G. R.
Background:- Helicobacter pylori (H.pylori) is a type of bacteria that causes infection in the stomach. It is the main cause of peptic ulcers, and it can also cause gastritis and stomach cancer. Tests and procedures for diagnosis of H.pylori include blood test, especially Rapid Urease Test(RUT positive).Bismuth quadruple therapy (BQT), consisting of a proton pump inhibitor(PPI), Bismuth and two antibiotics (Doxycycline and Nitroimidazole) has been recommended in most current H.pylori treatment guidelines as a first line regimen. Method:-This is a Prospective Observational Study carried out in 20 patients.In this study, we assess the symptomatic improvement caused by Bismuth regimen therapy in H.pylori gastritis patients. The H.pylori patients were given Bismuth subsalicylate, PPI, Doxycycline and Nitroimidazole. The primary endpoint of this study was to evaluate the efficacy and side effects of Bismuth quadruple therapy. The efficacy will be assessed using GSRS(Gastrointestinal symptoms rating scale) and side effects by questionnaire. Result:- A total of 20 patients with H.Pylori gastritis fulfilling the study criteria were selected. Bismuth quadruple therapy was given for all patients and their symptomatic improvement and side effects were assessed. Almost all the patients found to relieve symptoms. Most subjects experienced some minor side effects during the course of therapy. There was no mortality or major morbidity recorded in the study. It was observed that bismuth quadruple therapy have maximal beneficial effect for H.Pylori gastritis patients. Conclusion:- From this study, it was concluded that Bismuth Quadruple therapy consisting of PPI, Doxycycline, Bismuth subsalicylate and Nitroimidazole has more efficacy with minimal side effects seems to be better treatment option.
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