EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A COMPARISON OF NEONATAL THYROID PARAMETERS OF CORD BLOOD AND NEWBORN VENOUS BLOOD AMONGST NEW-BORNS OF AVMC

Dr. Murali Krishna*, Dr. Rengaswamy, Dr. Nalini and Dr. Raghupathy

ABSTRACT

Background: Hypothyroidism may be congenital or may be acquired which might or may not have a delayed onset. Incomplete thyroid development and decreased thyroid hormone biosynthesis is a result of congenital hypothyroidism. Screening is usually missed in areas where testing is not done and is the reason for new cases of hypothyroid cases. India has a higher incidence of neonatal hypothyroidism. Aim: To evaluate whether cord blood can be used as a primary thyroid screening tool. Method: The study was taken up in the department of pediatrics of a tertiary teaching hospital. A total of 200 babies were taken for the study during the whole study period. The cord blood at the time of delivery and 48-hour serum blood was collected and sent to the lab for thyroid profile estimation. Results: The study consisted of 106 males and 94 female infants. Among the 200 subjects, 167 were term babies and 33 were preterm. The mode of delivery was 77.5% had lower segment cesarean section and the remaining 22.5% were normal deliveries. The mean birth weight was 2.810 kgs. The mean TSH 6.99±4.81, the mean T3 level was 80.43±39.06 and the meanT4 level among the subjects was 10.90±4.59. The systemic venous blood was collected after 48 hours for thyroid profiling. The mean TSH was 4.65±4.03, the mean T3 level was 114.205±38.27 and the mean T4 level among the subjects was 13.89±5.60. On comparison of cord blood, TSH and systemic venous blood TSH association were noted which was statistically significant. Association was between cord blood T3 and 48-hour venous blood was present and statistically significant. Cord blood for T4 and venous blood for T4 association was seen and statistically significance present. Conclusion: from the present study, it can be suggested cord blood can be used as a marker for thyroid screening tool.

Keywords: Cord blood, Systemic Venous blood, TSH, T3, and T4.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )