EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

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 ICV - 79.57

Abstract

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTRACT OF GLYCOSMIS PENTAPHYLLA IN HYPERLIPIDEMIC WISTAR RATS

Syed Safiullah Ghori*, M.A Rizwan Khan,Kaab e Alam,Abid Hussain Abrar,

ABSTRACT

The present study was designed to perform preliminary phytochemical
screening, acute oral toxicity and to evaluate antihyperglycemic
activity of whole plant of Glycosmis pentaphylla ethanolic extract.
.Glycosmis pentaphylla,whole plant was extracted using ethanol as
solvent by soxhlet apparatus. The extract was subjected to preliminary
phytochemical screening. Acute oral toxicity studies were performed
to determine test dose. The evaluation of antihyperlipidemic activity was done using Triton
X 100 and High Fat Diet induced hyperlipidemia models in Wistar albino rats. Preliminary
phytochemical screening revealed the presence of alkaloids, carbohydrates, glycosides,
saponins, tannins, flavonoids, proteins, and amino acids. Doses up to 2000mg/kg were found
to be safe after acute toxicity tests. Cholesterol, triglycerides, HDL, LDL, VLDL, SGOT,
SGPT, Total protein and glucose were measured. The results suggested that EGP (ethanolic
extract Glycosmis pentaphylla) possess antihyperlipidemic activity against hyperlipidemia
induced by Triton X 100 and also High Fat Diet induced experimental models.

Keywords: Glycosmis pentaphylla,ethanolic extract, Triton-X, HFD, hyperlipidemia,.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia