A REVIEW ON PHARMACOLOGICAL ACTIVITY AND SYNTHETIC METHODS OF BENZOTHIAZOLE NUCLEUS

Dr. Sanjay Singh, Manisha Negi*, Gaurav Kumar and Mamta

ABSTRACT

Benzothiazole is one of the most important heterocyclic compound, weak base, having varied biological activities and still of great scientific interest now a days. They are widely found in bioorganic and medicinal chemistry with application in drug discovery. Benzothiazole are fused membered rings which contain heterocycles bearing thiazole. Sulphur and nitrogen atoms constitute the core structure of thiazole and many pharmacologically and biologically active compounds. Benzothiazole is among the usually occurring heterocyclic nuclei in many marine as well as natural plant products. Benzothiazole is known to exhibit a wide range of biological properties including anticancer, antimicrobial, and antidiabetic, anticonvulsant, anti-inflammatory, antiviral, antitubercular activities.

Keywords: Benzothiazole, Pharmacological activities, antimicrobial activity, anti malerial activity, anti bacterial, anti fungal activity.