EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COAGULATION PROFILES OF ADULT SICKLE CELL PATIENTS IN STEADY STATE

Ajayi A. Ibijola*, Abiodun I. Okunlola and Omotola T. Ojo

ABSTRACT

Background: Sickle cell disease is considered to be a prothrombotic state and this has a lot of influence on the associated complications of this disease condition if not put into consideration during the course of treatment. Therefore, the knowledge of the coagulation profiles in these patients will improve the treatment outcome especially during the periodic crises and perioperative period. Objective: To evaluate coagulation profiles of the adult sickle cell patients in steady state. Methods: This is a comparative cross sectional study. Forty HbS patients in steady state attending Haematology clinic and 40 age and sex matched healthy HbAA controls were recruited. Liver function (LFT) was done with Hitachi 912. Results: Both males and females HbS patients had relatively higher median APTT than their male and female counterparts in the control subjects. (P=0.025). Male HbS patients had higher median (25-75 percentiles) Prothrombin Time than their counterparts in the control group. The female HbS patients had similar median Prothrombin Time with the control subjects. The median test shows no statistically significant difference in the prothrombin time between the HbS patients and the control HbA patients (P=1.000). Conclusion: Coagulation profile in sickle cell patients in steady state is higher compared with the HbA control subjects but this is not statistically significant. The prolonged coagulation profile may be as a result of increased consumption of coagulation factors following activation of coagulation and fibrinolytic systems in sickle cell patients even at steady state and not necessarily due to hepatic dysfunction.

Keywords: Sickle cell anaemia; coagulation profile; steady state; adult patient; liver function.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )