EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HISTOMORPHOLOGICAL AND HAEMATOLOGICAL EFFECT OF AQUEOUS EXTRACT OF CASSIA OCCIDENTALIS LEAF ON OF THE HEART OF ADULT WISTAR RATS

*Ekundina VO, Ebeye OA, Ade Alabi and Sokoh GK

ABSTRACT

This research accessed the effect of aqueous extract of Cassia occidentalis leaf on some hematological parameters and Microanatomy of the heart. Twenty (20) Adult rats with an average weight of 150g were randomly placed into 4 groups. Each group consisted of five (5) rats, group 1 served as the control group while groups 2, 3 and 4 were given 100mg, 200mg, and 300mg of cassia occidentalis extract respectively for 28 days after which all animals were sacrificed by cervical decapitation and the heart harvested were fixed promptly using 10% formol- saline after which the tissues were processed to obtained routine paraffin sections. The result revealed dose dependent increase in the levels of the PCV, Neutrophil, and lymphocyte while the WBC revealed a dose dependent reduction, the Eosinophil and Monocyte count were unremarkable. Histopathological studies of the heart showed a variant of tissue separation, congestion and other adaptive features which was concentration dependent and also showed a level of chronic inflammation in the 300mg/kg dosed rats. The study concluded that aqueous extract of Cassia occidentalis leaf has immunogenic properties however further works should be carried out so as to assess more beneficial or hazardous effect of the plant.

Keywords: Cassia Occidentalis, Wistar rat, Haematology and Histology.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )