EFFECT OF XYLOPIA AETHIOPICA (NIGRO PEPPER) ON SOME BLOOD PARAMETERS IN MALE WISTAR RATS
Nsimah Monday Essien, Charles Cyprian Mfem, Sunday Okpa*, Justina Nwandimma Nwangwa, Ernest Atelhe Amama, Clement Lishilinimye Ushuple, Kendrick Okay Ococoh, Inah Onete Inah, Mfon Jeremiah Akpan
Background: This study investigated the effects of Xylopia aethiopica (Nigro pepper) on some blood parameters in male Wistar rats. Materials and Methods: Ten Wistar rats weighing 160 – 200g were divided into two groups (n=5). Control group received rat feed and water while the Xylopia aethiopica extract treated group received 10mg/kg b.w of the extract orally for 28 days. Results: Red cell distribution width, platelet count, plateletcrit, mean platelet volume, platelet distribution width and platelet large cell ratio were not significantly different between the two groups. Conclusion: The ethanolic extract of Xylopia aethiopica at a low dose of 10mg/kg b.w showed no significant effect on red cell distribution width and platelet indices. Further studies at higher doses of Xylopia aethiopica are encouraged to establish their clinical relevance in the management of hematological disorders.
Keywords: Xylopia aethiopica, blood, red blood cell, platelet.
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