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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Pharm. Ogira Johnson Ogwuche*, Prof. Onah Johnson O., Dr. Odumosu Patricia and Dr. Ajima Ukpe


Objective: The objective of the project was to study the physico-chemical characteristics of the chitosan and polyethylene glycol polymer conjugates of ciprofloxacin and moxifloxacin. In spite of the strong activities of these drugs the experiment was to evaluate their activities in conjugated forms and to assess whether this will confer any special advantage. Methodology: The conjugates were prepared by esterification reactions. The drug-to carrier ratios were determined. The ester conjugates were characterised by melting point, UV, IR, solubility in different solvent systems after which they were subjected to stability tests (hydrolysis) in different buffers systems. Half-lives were also estimated. Microbiological evaluations of the conjugates were determined. Results: Evidence for ester formation was observed from the physicochemical changes indicated below. The UV absorption maxima for pure ciprofloxacin, moxifloxacin, chitosan and polyethylene glycol were 270 nm; 295 nm; 260 nm, 240 nm respectively while ciprofloxacin-chitosan and moxifloxacin-chitosan, ciprofloxacin- PEG and moxifloxacin-PEG were 300 nm, 270 nm, 280 nm and 300 nm respectively. The drug - to- carrier ratios were found to be: Cipro - Chitosan; 1.0 : 5.1; Moxi- Chitosan, 1.0 : 4.7; Cipro - PEG. 1.0 - 1.1 and Moxi - PEG, 1.0: 1.05. The infrared spectra showed characteristic absorption bands in the carbonyl region (1700cm-1 and 1800 cm-1). The melting points for ciprofloxacin-chitosan, moxiflolxacin-chitosan, ciprofloxacin-PEG and moxifloxacin-PEG were 245-248oC; 270 - 275oC; 280-283oC and 290-293oC respectively. All the conjugates were insoluble in ethanol, diethyl ether, n-hexane and acetone but soluble or sparingly soluble in water, methanol, and glacial acetic acid, hydrochloric and sulphuric acids. Hydrolysis constants for all the conjugates showed linearity for between 0 and 8 hours and flexes into a plateau at 10 hours in phosphate buffered solutions of pH 6.1, pH 7.4 and pH 8.1. Corresponding regression equations were generated. The rates of hydrolysis of all the conjugates at pH 6.1 varied from 1.73 to 9.04 x 10-2 s-1; at pH 7.4 the rate varied from 1.47 to 8.54 x 10-2 s-1 and at pH 8.1 the rate varied from 2.85 to 9.60 x 10-2.s-1 The corresponding half-lives of hydrolysis varied from 5.1 to 40.8 hours; at pH 7.4 the half-life varied from 8.1 to 47.0 hours and at pH 8.1 the half-life varied from 7.2 to 24.3 hours. Antimicrobial activities of the conjugates against Staph. aureus, Staph. pneumonia, E.coli, Salmonella typhi and Pseu. aeroginosa. showed enhanced sensitivity of between 40 and 50%.

Keywords: Polymers, Conjugates, Moxifloxacin and Ciprofloxacin.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )