GENOPROTECTIVE POTENTIAL OF ALLIUM SATIVUM AGAINST CHEMICAL CLASTOGENS

Kiran Chauhan* and Sanjay Kumar Narang

ABSTRACT

Clastogenicity is an induction of changes in structure of chromosomes, which is dangerous to any organisms. In concern to mutation, the clastogenicity is structural chromosome aberrations produced by some clastogens, which cause breaks in chromosomes and resulted in either loss or re-shifts of chromosomal segments. In treating mutagenicity, compared to modern medicine, the traditional herbal medicine based on medicinal plants has some ability to cure without worsening the condition. Chromosomal aberrations based human syndromes are very critical and sometimes leads to lethality. Such syndrome or disorders are often irreversible. In this present study, we evaluated the anticlastogenic effect of Allium sativum (garlic) against chromosomal aberrations induced by K2Cr2O7 and EMS in bone marrow cells of mice. The results showed that the clastogenic effect was minimized by Allium extract in mice model.

Keywords: Clastogenicity, Chromosomal aberrations, Genoprotective, Allium.