EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

COMPARATIVE ANTIMICROBIAL AND CYTOTOXIC ACTIVITY STUDY OF N-HEXANE, CHLOROFORM AND CARBON TETRA-CHLORIDE EXTRACTS OF ADIANTUM INCISUM FORSK

Sayema Khanum* and Dewan Aklima

ABSTRACT

In the present study the antimicrobial & cytotoxic activity of crude extracts (n-hexane, chloroform, carbon tetra-chloride) of Adiantum incisum Forsk were studied. Antimicrobial activity was tested against ten important pathogenic bacteria including both gram positive (+ve) and gram negative (-ve) bacteria and two fungi. The bacteria were B. megaterium, B.cereus, B. subtilis, Staphylococcus aureus, Sarcina lutea, Escherichia coli, Shigella boydii, Pseudomonas aeruginosa, Vibrio mimicus & V. parahemolyticus. Disc diffusion technique was used for in-vitro antibacterial and antifungal screening. Here kanamycin disc (30g /disc) was used as standard for antibacterial study. The extracts showed antimicrobial activity against most of the bacterial strains with an average zone of inhibition of 8-14mm. The tested fungi were Saccharromyces cerevaceae and Candida albicans. The extracts showed mild to moderate antifungal activity with an average 8 -10 mm zone of inhibition. Among the three solvent extracts used, the most effective extract was found to be chloroform and maximum activity (14 mm, zone of inhibition) found against Staphylococcus aureus. Cytotoxicity test was also studied by Brine Shrimp Lethality Bioassay and compare with LC50 values of standard Vincristine sulphate as a positive control. The results illustrated significant cytotoxicity against A. salina, with LC50 9.267μg/ml, 8.118μg/ml and 9.245μg/ml for n-hexane, chloroform and carbon tetra-chloride extracts respectively.

Keywords: Antimicrobial activity, Pathogenic bacteria, Kanamycin, Cytotoxicity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia