CHRONIC LIVER INVOLVEMENT IN SICKLE CELL DISEASE: A CASE REPORT
*Tlili Raja, Kchir Hela, Ayadi Rahma and Maamouri Nadia
We present the case of a 30-year-old male with sickle cell disease who developed an acute vaso-occlusive crisis occurring in chronic hepatopathy. Admitted with abdominal pain, jaundice and fever, precipitated by septic arthritis. The laboratory assessment showed elevations of the liver enzymes, cholestasis associated with hyperbilirubinemia (predominantly unconjugated), slight thrombocytopenia and low prothrombin rate. Abdominal ultrasound and cross-sectional imaging demonstrated: fine bile ducts and cholelithiasis, hepatomegaly, dysmorphic liver, splenomegaly and moderate peritoneal effusion. A liver transplant and exchangetransfusion were necessary for severe hepatocellular insufficiency and edema-ascitic syndrome. But the patient died during transplantation planning.
Keywords: Sickle cell hepatopathy, Sickle hepatic crisis, Exchange Transfusion, Liver Transplantation.
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