EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

EFFECTS OF ORAL ADMINISTRATION OF ETHANOLIC LEAF EXTRACT OF MUCANA PURIENS OBTAINED FROM AFIKPO ON SERUM BIOCHEMICAL PARAMETERS AND ELECTROLYTES IN ALBINO WISTAR RATS

*N.A. Obasi, S.E. Obasi, C.O. Egwu, G. Otuchristian and F.N. Nkasi

ABSTRACT

The effects of oral administration of ethanolic leaf extract of Mucana puriens obtained from Afikpo, Ebonyi State, Nigeria for 28 days on some serum biochemical parameters and electrolytes of albino wistar rats were investigated using standard protocols. Thirty-two (32) albino rats comprising 16 males and 16 females were used for the study. The rats were divided into four groups namely A, B, C and D. Each group was made up of 4 male and 4 female rats separated but given similar treatment. Group A served as the control and were treated with normal saline (0.4ml/100g body weight). Each of groups B, C, and D were administered through oral intubation 250 mg/kg body weight, 500 mg/kg body weight and 750 mg/kg body weight of extract respectively. The result of acute toxicity test obtained showed a lethal dose (LD50) of greater than 5000mg/kg body weight of the extract. Results indicated that administered doses of 250, 500 and 750mg/kg body weight of the leaf extract showed significant (P < 0.05) increase in body weight, serum total protein and albumin and significant decrease in serum total bilirubin, uric acid, urea and creatinine in a dose dependent manner. Non-significant (P > 0.05) increase was observed in serum Na+, K+, Cl-, Mg2+, Ca2+ and inorganic P at all doses except for Ca2+ and inorganic P whose increase was significant at a dose of 750mg/kg body weight of extract. These results are indications that the extract is biochemically safe and could have beneficial health effects.

Keywords: Mucana puriens, Biochemical parameters, Electrolytes, Health, Afikpo.


[Full Text Article] [Download Certificate]

Citation

  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 March 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR: MARCH ISSUE PUBLISHED

    MARCH 2024 issue has been successfully launched on MARCH 2024.

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia