( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Shivanand Kolageri*, B. Shivakumar, S. M. Biradar, Santosh Karajagi and E. N. Gaviraj


Six new derivatives of 3-(4-oxo-2-arylthiazolidin-3-yl)-2-methylquinazolin-4(3H)-one were synthesized by condensation between 3-amino-2-methylquinozolin-4(3H)-one and substituted aromatic aldehydes using thioglycolic acid, N,N’-dicylohexylcarbodiimide and N,N-dimethyl formamide as solvent. The required 3-amino-2-methylquinozolin-4(3H)-one was obtained from the reaction between 2-amino benzoic acid and acetic anhydride/acetyl chloride. The synthesized compounds containing quinazoline nucleus coupled with thiazolidinone could yield effective biologically active derivatives. Hence the objectives of the research work are as synthesize newer heterocyclic derivatives of Quinazolinones with thiazolidinone, characterize the synthesized compounds using physical data like M.P, TLC and spectroscopic analysed FT-IR, 1H-NMR Spectral and these synthesized compounds were biological evaluated for their antimicrobial screening. The prepared compounds were confirmed for antibacterial activity against E. coli (gram negative) and Staphylococcus Aureus (gram positive) by using cup-plate method. The results of antibacterial activity revealed that, among all derivatives 3-[2-(2-chloroquinolin-3-yl)-4-oxo-1,3-thiazolidin-3-yl]-2-methylquinazolin-4(3H)-one showed moderate to good activity and others showed moderate to weak activity at the concentration of 250μ/ml, 500μ/ml and 750μ/ml compared to Chloramphenicol drug.

Keywords: Quinazolinones with thiazolidinone derivatives, Antibacterial activity, Cup-plate method.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database