EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND IN-VITRO EVALUATION OF SOLID LIPID NANOPARTICLES CONTAINING DEXAMETHASONE

Sonali Suryawanshi*, Jyoti Sonawane, Amit Chaudhari, Yogita Ingle, Siddiqua Shaikh and Vishal Chavhan

ABSTRACT

The present study aims on preparing dexamethasone loaded solid lipid nanoparticles (SLNs) to reduce the dose, frequency of dosing, reduce side effects and to increase the bioavailable fraction of drug (<30% orally in general). A total of 16 formulations were prepared (8 for each lipid i.e. Stearic acid and Palmitic acid; SF1-SF8 and PF1-PF8 respectively) Optimized formulations were characterized for particle size analysis, , drug entrapment efficiency and in vitro drug release study. The particle size of SF1, SF2, SF6, PF1, PF2 and PF6 was measured to be 124.5 nm, 136.4 nm, 154.4 nm, 130.4, 167.5 and 146.2 nm respectively using Microscopic method, which was in desired range. SLN formulations were found to be stable with drug entrapment efficiency was reported to be approximately 90% for selected formulations. From in vitro drug release study, the % cumulative drug release after 24 hrs from SF1, SF2, SF6, PF1, PF2 and PF6 was recorded to be 93.44, 90.20, 85.58, and 92.33, 89.44, 88.58 respectively. Mechanism of drug Release was found to follow Higuchi diffusion model; Fickian diffusion for SF batch formulations and non-Fickian diffusion for PF batch formulations. The highest cumulative % drug releasing formulation from each batch (i.e. SF1 and PF1) was chosen for further evaluations. The SLNs appeared to be less dense in the core with a well-defined shell. The successful incorporation of Dexamethasone into SLNs opens a wide scope of the study of the delivery system with respect to sustained and targeted drug delivery. However the in vivo studies are yet to be carried out to confirm the potential of formulated SLNs.

Keywords: Dexamethasone, Stearic acid. Palmitic acid, Solid Lipid Nanoparticles.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )