EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

SERUM ASSESSMENT OF DOGS EXPERIMENTALLY INFECTED WITH SINGLE TRYPANOSOMA CONGOLENSE AND CONJUNCT TRYPANOSOMA CONGOLENSE AND ANCYLOSTOMA CANINUM INFECTIONS AND TREATMENT WITH DIMINAZENE ACETURATE AND MEBENDAZOLE

*Nwoha R. I. O. and Anene B. M.

ABSTRACT

Aim: The health dangers associated with disease caused by different species of trypanosomes in dogs necessitated the serological assessment of dogs experimentally infected with single Trypanosoma congolense (T.congolense) and conjunct Trypanosoma congolense (T.congolense) and Ancylostoma caninum (A.caninum) infections and treatment with diminazene aceturate and mebendazole. Materials/ methods: Twelve mongrels of both sexes weighing between 4 to 8 kg were used in the study. They were randomly grouped into 3 to 4 members each. Group I was uninfected control, Group II was infected with T.congolense, Group III was infected with conjunct T.congolense/A.caninum. Post acclimatization, GPII was infected with 200 L3 infective dose of A.caninum. Two weeks post infection 2.5 x106 doses of T.congolense was used to infect GPII and GPIII. Result: Results show a significant increase (p<0.05) in total protein, bilirubin and cholesterol level of GPII and GPIII. Transient increase in calcium ion was recorded only in GPII. Conversely a significant decrease (p<0.05) in albumin was recorded in both GPII and GPIII. Conclusion: The biochemical alterations were more severe in mixed infection of T.congolense/A.caninum compared to single T.congolense. Treatment improved altered serum analytes. Hence against this backdrop effort must be put in place to prevent its occurrence in dogs.

Keywords: total protein, albumin, calcium ion, bilirubin, cholesterol, T.congolense, A. caninum.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia