A REVIEW ON BIOLOGICAL ACTIVITY OF DIHYDROPYRIMIDINONE (DHPM) DERIVATIVES:
Dr. Abhishek Soni, Priyankul Palia, Nagesh Kumar* and Mukul Sharma
The most important heterocyclic ring systems that play a role in the synthesis of DNA and RNA are
dihydropyrimidines. They were made synthetically using multi-component reactions such as the Biginelli reaction
and the Hantzschdihydropyridine reaction. Due to the interesting pharmacological properties associated with this
heterocyclic scaffold, Biginelli type dihydropyrimidones have received a lot of attention in recent decades. In this
review, we concentrate on the DHPMs, which have recently been developed as calcium channel antagonist, antiinflammatory,
anti-tubercular, anticancer, and antibacterial activities.
Keywords: heterocyclic scaffold, Biginelli type dihydropyrimidones.
[Full Text Article]