EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

A COMPARATIVE STUDY OF EFFICACY WITH FIXED DOSE COMBINATION OF LATANOPROST/ TIMOLOL VERSUS BRINZOLAMIDE/ BRIMONIDINE IN PRIMARY OPEN ANGLE GLAUCOMA

Chawla S.*, Kaushal J. and Sachdeva S.

ABSTRACT

Objective: To study efficacy with fixed dose combination of latanoprost/ timolol versus brinzolamide/brimonidine in primary open angle glaucoma. Material & Methods: A prospective, randomized, comparative, clinical study was conducted on 50 patients. The patients were randomly divided in two groups of 25 each to receive following two treatments: Group A (n=25) Latanoprost and Timolol (0.005+0.5%w/v) ophthalmic solution once daily; Group B (n=25) Brinzolamide and Brimonidine (1%+0.15%w/v) ophthalmic solution thrice daily for 12 weeks. Efficacy assessment was done at the end of 2, 4, 6 and 12 weeks by observing Intra Ocular Pressure (IOP), visual acuity assessment, number of patients having headache, eye-ache & assessment of VAS score for headache & eyeache was also done. Results: Intraocular Pressure assessment using Goldmann applanation tonometer was done in both the groups. IOP in Group A at the end of 12 weeks was 19 as compared to 27.6 at the baseline while in group B it was 20 as compared to 26.76 at the baseline. The difference was statistically significant at the end of 12 weeks; p<0.001. Improvement in mean vision in Group A was more than Group B at the end of 12 weeks (33.3% Vs 15.2%) but the difference was not statistically significant. Reduction in VAS score for headache & eye-ache was more with Group A as compared to Group B at the end of 12 weeks but the difference was statistically different.

Keywords: Latanoprost, Timolol, Brinzolamide, Brimonidine, Intra Ocular Pressure, Mean vision, headache, eye-ache, visual acuity score.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )