EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE COMPARATIVE STUDY BETWEEN OBETICHOLIC ACID AND URSODEOXYCHOLIC IN NONALCOHOLIC STEATOHEPATITIS (NASH) MANAGEMENT

Md. Kutub Uddin Mollick*, Sukumar Saha, Utpal Kumar Chanda, Gazi Salahuddin and Mamun Al Mahtab

ABSTRACT

Objective: In this study our main goal is to evaluate the effectiveness of obeticholic acid and ursodeoxycholic in non alcoholic steatohepatitis management. Method: This cross sectional study was carried out at Tertairy Medical hospital January 2019 to January 2020. Where a total of 60 patients with a clinical and laboratory diagnosis of NASH, on a stable dose of UDCA for at least 6 months prior to screening, were randomly assigned (1:1:1) to one of three treatment groups for 85 days (3 months): OCA 10 mg, OCA 25 mg, OCA 50 mg or a matching placebo administered once daily. Results: During the study, out of 60 patients (40%) were 30 or below 30 years old, (26.6%) 31-40 years and (20%) 41-50 years and majority were male, 80%. C-reactive protein (CRP) showed significant reductions from baseline at the end of the study with OCA treatment. In OCA 25 mg group Improvement of fibrosis was 24% without worsening of NASH and 12% resolution cases of NASH with no worsening of fibrosis. Conclusion: Daily doses of OCA, ranging from 10 to 25 mg, significantly reduced levels of ALP, lipid profile, and alanine aminotransferase, compared to placebo, in patients with NASH who had inadequate responses to UDCA. Further study is needed for better outcome.

Keywords: obeticholic acid (0CA), ursodeoxycholic, nonalcoholic steatohepatitis (NASH).


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )