EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CLINICAL EFFICACY AND SAFETY OF TRIPLE COMBINATION CREAM CONTAINING MOMETASONE FUROATE, MICONAZOLE NITRATE, AND GENTAMICIN AS A TOPICAL TREATMENT FOR MIXED SKIN INFECTIONS WITH FUNGI AND BACTERIA

*Mai Hussein El-Samahy, Eman Moustafa Kamel Ahmed Sanad, Basma Mourad Mohamed Aly, and Samia Mohamed Essmat Mahmoud

ABSTRACT

Background: Fixed dose combinations of corticosteroids, antibacterials and antifungals are known to alleviate inflammatory skin conditions. This study aimed to evaluate the safety and clinical efficacy of the topical application of a triple combination of mometasone furoate, miconazole nitrate and gentamicin in a cream base for mixed skin infections. Materials and Methods: Patients with mixed skin infections were prescribed Momenta™ cream, at the sole discretion of their physicians, for 7 to 14 days. Results: A total of 416 patients were enrolled from 4 sites in this study; of which, 375 were eligible for primary efficacy analysis. The median (IQR) total score of all signs and symptoms was significantly decreased from 11 (7) at baseline to 1 (3) at the end of treatment duration, with a median reduction of 10 points (p < 0.0001). At the end of treatment, 89.9% of patients achieved ≥ 50% relative improvement in total score of all signs and symptoms. A total of 4 patients experienced 7 adverse events during the study period. Pruritus was reported by 4 patients while burning sensation was reported by 3 patients. None of the events was serious. Conclusion: The triple combination cream of mometasone furoate, miconazole nitrate and gentamicin have acceptable efficacy and safety profile in the treatment of mixed skin infections with bacteria and fungi.

Keywords: skin conditions, antibacterials, antifungals, corticosteroids, mixed infections


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )