EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ESTIMATION OF SERUM INTERLEUKIN-18 IN CHRONIC HEPATITIS C VIRUS-INFECTED PATIENTS

Eman Ahmed Eissa, Hamed Mohamed Abd El Barry, Shuzan Ali Mohammed*, Amal Salah Abd El Hamid Ewies and Ibrahim El Tantawy El Sayed*

ABSTRACT

Background: Hepatitis C virus (HCV) infection is a major global health problem and is one of the main causes of chronic liver disease One of the most countries affected by HCV is Egypt. IL-18 plays a crucial role in the inflammatory cascade. The aim was to evaluate Il-18 as a marker for the severity development of hepatic cirrhosis in chronic hepatic C patients. Methods: This prospective a case-control study which conducted on 100 patients with post-hepatitis C liver. In addition to 50 healthy subjects served as a control group. IL-18 were measured for all participants Results: Serum liver enzymes (ALT and AST) differ significantly (P < 0.01) among different groups. The higher ALT and AST level observed in cirrhotic group followed by non-cirrhotic group and the lower ALT and AST level observed in control group.IL-18 protein level differ significantly (P < 0.01) among different groups. The higher IL-18 observed in cirrhotic group followed by Non-cirrhotic group and the lower IL-18 observed in the control group. There were significant positive correlations between serum levels of IL-18 and (AFP, INR, ALT, AST, virus number, total bilirubin and direct bilirubin). Conclusion: IL-18 levels were elevated in HCV patients than controls. Serum IL-18 is significantly increase in HCV patients and is correlated with liver cirrhosis. So, IL-18 can be used as non-invasive pro inflammatory marker for detection of the chronicity and severity in chronic hepatitis c patients.

Keywords: Il-18- hepatic cirrhosis- chronic hepatic C patients.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )