EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ASSOCIATION BETWEEN COMPLEMENT COMPLEX C5B-9 WITH RHEUMATOID ARTHRITIS IN AN IRAQI POPULATION

Ghadaq Hameed Neamaa* and Amjed Mohammed Sahib

ABSTRACT

Purpose: Investigating the level of concentration of complement complex C5b-9 in RA patients and controls serum. Methods: allow 2 ml blood samples to clot for 2 hours at room temperature or overnight at 4 C after that the samples were centrifuged for 15 min at 1000xg. Then, the the supernatant was collected and separated in plastic plain tube at deep freeze (-20 C˚) to be used for determine the concentration of complement complex C5b-9 in the serum of cases and controls. The complement complex C5b-9 concentration levels were investigated in 55 RA patients and in 32 healthy controls by using ELISA test. Results: The complement complex C5b-9 concentration levels were investigated in 55 RA patients and in 32 healthy controls. There is no significant difference when the mean of concentration level is compared in patients sera with the mean of concentration level in control sera. When the complement complex is used as a diagnostic test according to ROC curve, it appeared not beneficial for the diagnosis of RA when compared with Rheumatoid Factor (RF) and ACCPs (Anti Cyclic Citrullinated Peptide antibodies). Conclusion: there were many laboratory diagnostic tests to the diagnosis of RA like CRP, RF and ACCP but the ACCP antibodies test was more specific for predicting and/or diagnosing RA. and the Complement complex C5b-9 was not beneficial for prediction the diagnosis of RA. there is a significant difference when the mean of complement complex is compared according to positive and negative RF test among cases with RA.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )