CHEMICAL CONSTITUENTS FROM THE BARK OF ALBIZIA LEBBECK (L.) BENTH., AND WHOLE PLANTS OF ANDROGRAPHIS PANICULATA (BURM. F.) NEES AND PARTHENIUM HYSTEROPHORUS L.

Mohammed Ali*, Showkat Rassol Mir, Shahnaz Sultana, Dolly Rani and Prem Kumar Dantu

ABSTRACT

Albizia lebbeck (L.) Benth. (family Fabaceae) is a fast-growing, medium-sized deciduous tree. Its stem bark is used to treat allergic disorders, anxiety, depression, diarrhoea, dysentery, flu, eye, genital, liver, lung and skin diseases, gingivitis, gonorrhoea, helminth infection, leucorrhoea, paralysis, piles, spermatorrhoea, animals bites and stings and wounds. Andrographis paniculata (Burm.f.) Nees (family Acanthaceae) is an annual, branched, erect, herbaceous plant. The plant is used to treat allergies, respiratory, liver, skin and stomach diseases, cholera, diabetes, dysmenorrhoea, gonorrhoea, scalp hair loss, influenza, insect and snake bites, kidney problems, leucorrhoea, malaria, osteoarthritis, piles, rabies, sinusitis, sore throat, sprain, syphilis, tuberculosis, ulcers, worms and wounds. Parthenium hysterophorus L. (family Asteraceae) is the worst toxic weeds responsible for severe human and animal health disorders, such as dermatitis, asthma, bronchitis, skin lesions, watery eyes, swelling and itching of the membranes of the mouth and nose, coughing, continually running nose, sneezing, itching of the mouth and fatigue. Our study was planned to isolate chemical constituents from the methanolic extracts of these plants and to characterize their structures on the basis spectral data analysis. Phytochemical investigation of the stem bark of Albizia lebbeck led to isolate a di-β-D-glycoside identified as β-D-glucopyranosyl-(6→1′)-O-β-D-glucopyranoside (1). The methanolic extract of the whole plant of Andrographis paniculata afforded two aliphatic alcohols recognized as n-triacont-3,7,11,15,19,23-hexaene-1-ol (2), a new aliphatic unsaturated higher alcohol and heneitriacontan-1-ol (3), a rare aliphatic higher alcohol. The methanolic extract of the whole plant of Parthenium hysterophorus furnished a sesquiterpene lactone characterized as 1β-hydroxy-12,14-dihydroparthenin-15-olyl oleate (4), a new pseudoguainolide.

Keywords: Albizia lebbeck stem bark, Andrographis paniculata plant, Parthenium hysterophorus plant, phytoconstituents, isolation, characterization.