MICROSPONGE: A NOVEL APPROACH FOR TOPICAL DRUG DELIVERY SYSTEM

Rakesh S. Pawara*, Nileshwari P. Chaudhari, S. A. Tadavi and S. P. Pawar

ABSTRACT

Microsponge technology is a novel technique was introduced in topical drug delivery of formulation to facilitate the controlled release of active drug into the skin. Microsponges are similar to the polymeric porous microspheres. Microsponges are reduces the systemic exposure and minimize the local cutaneous reaction to active drug. The microsponges are 5-300 μm in diameter, spherical shape, large porous surface& tiny in structures. Nature of the microsponges is non-irritant, non-allergic, non-mutagenic and non-toxic. Most of the microsponge’s formulation is used for topical drug delivery system as well as they are used in oral administration. Deliver the drug of microsponges in regular time of interval and response to the other stimulation. Advantages of the microsponges are mainly release of the drug and enhance the stability and effectively reduce the side effect of drug. Achieve the desired concentration of the drug in the blood is the main Aim of the formulation. microsponges are generally used in a topically the prevent of the accumulation of drug in dermis and epidermis Microsponges are easily entrapped or incorporated into formulated product such as creams, liquids, gels, powders, suspension.

Keywords: Topical & oral administration, 5-300 ?m, polymeric porous, stability.