EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

ANTI-INFLAMMATORY ACTIVITY OF ACACIA CONCINNA

Megha Agrawal* and Dr. Vijay Patel

ABSTRACT

The aqueous extract of the pods of Acacia concinna was investigated for its anti-inflammatory activity using carrageenan induced paw edema and cotton pellet granuloma models in wistar rats. A statistically significant (p<0.01) dose and time dependent inhibition of edema was observed. The observed % inhibition of edema was 77.78, 69.44 and 62.04% for ibuprofen and plant extract with 100 and 200 mg/kg dose, respectively. Also, the plant extract significantly inhibited (p<0.01) the granuloma induced by cotton pellets in rats in a dose-dependent manner. The % granuloma inhibition was 51.21, 26.12 and 30.59% for ibuprofen and plant extract at doses of 100 and 200 mg/kg respectively. It was concluded from the present study that extract of pods of A. concinna have significant anti-inflammatory activity.

Keywords: Anti-inflammatory, Acacia concinna, Paw edema, Cotton pellet granuloma.

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