BIOINFORMATIC ANALYSIS OF SELECTED PHYTOCHEMICALS, NATURAL COMPOUNDS AND PROTEINS FOR CIRRHOSIS

Manish Kumar, Sachin Verma, Mohit Mishra, Khushboo Rana, Mishka, Varsha Prajapati, Noopur Khare, Abhimanyu Kumar Jha and Neha Prakash Rai*

ABSTRACT

Cirrhosis is also called liver cirrhosis or hepatic cirrhosis and end-stage liver disease. Cirrhosis results in approximately 200,000 deaths per year in India, primary biliary cholangitis, and primary sclerosing cholangitis which can disrupt bile duct function, genetic disorders. Symptoms can include fluid build-up in the abdomen, jaundice, bruising easily, itchiness, swelling in the lower legs, and the development of spider-like blood vessels in the skin. Cirrhosis is also known to occur at the late stage of liver damage. The early stages of the liver disease led to the inflammation in the liver. It considers 4 stages in the early stages of liver disease. Several phytochemicals and natural compounds are used for the treatment of cirrhosis such as Alpha Hederin, Berberine, Curcumin, Epigallocatechin-3-Gallate, Ferulic Acid, Genistein, Ginkgolide, Luteolin, Oleanic Acid, Quercetin, Resveratrol, Thiophenes and Sulfonamides, Benzimidazole and Lidamycin. α-Hederin was present in attenuate hepatotoxicity in mice which can be induced due to several liver toxicants. Luteolin is a type of flavone that was chemically known as 2-(3,4-dihydroxy phenyl)-5,7-dihydroxychromen-4-one and may predominantly present in several types of plants, flowers, and fruits. The auxin binding protein is a family of proteins that can bind with auxin.

Keywords: Cirrhosis, Alpha Hederin, Luteolin, RARB and Auxin binding protein.