CORRELATION OF ABERRANT IMMUNOHISTOCHEMICAL EXPRESSION OF ABH ANTIGENS WITH POOR PROGNOSTIC FACTORS IN BREAST CARCINOMA

Anass Jarmoumi*, Soukaina Zouine, Salma Hasnane, Farida Marnissi and Norddine Habti

ABSTRACT

Studies of the expression of ABH antigens in different tissues have shown altered glycosylations related to the tumor process, inducing aberrant expressions correlated with advanced cancer stage and poor prognosis. Our main objective is to study experimentally the expression of ABH antigens on breast tumor tissues in a large sample of patients. This are an experimental study carried out on breast tumor tissue samples, from patients with blood group B. To further understand the modalities of ABH antigen expression in breast tumor tissue, and their association with breast cancer prognostic factors, an immunohistochemical study was performed on surgical specimens of breast tumor tissue, to verify the expression of HER2 receptors, B and H antigens. The study concerned 97 cases. Analysis of immunohistochemistry results of tumor tissues showed a loss of B-antigen expression in 83.5% of cases, of which 54.32% expressed H antigen. Loss of B-antigen expression is more observed in SBR III tumors with a percentage of 95.75%. The cases expressing the H-antigen are all SBR grade III. The patients presenting the profile antigen-B negative, and antigen-H positive have 91.2% of negative estrogen receptors. Estrogen receptors are negative in 78.9% of the B antigen negative patients. 86% of the tumor tissue of the B antigen negative patients is HER2 positive. The difference is significant (p<0,05) with patients who have maintained B expression and who are all HER2 negative. Aberrant expression, is related to the initial oncogenic transformation and may precede the specific symptomatology of malignant conversion.

Keywords: Antigens; Blood; Breast; Carcinoma; Histocompatibility.