ASSOCIATION OF ABO BLOOD GROUP AND BREAST CANCER IN CASABLANCA

Anass Jarmoumi*, Salma Hasnane, Soukaina Zouine, Farida Marnissi and Norddine Habti

ABSTRACT

The role of ABO blood group in cancer biology has been intensively studied by several researchers, and it is now widely recognized that ABH antigens are associated with the risk of developing several types of tumors. In order to elucidate this association with breast cancer, our objective is to verify the existence of a relationship between ABO blood groups, pathological data and prognostic factors of breast cancer. This is a retrospective, cross-sectional and monocentric study, carried out by a descriptive reading of the statistics of the ABO phenotypic, clinical and anatomopathological characteristics of the patients with breast cancer, having been followed in the service of Gynecology of the Mohammed VI Center of the University Hospital of Casablanca. The percentages of blood groups found in this sample were compared to the average phenotypic frequencies of 344,954 blood donors listed in 14 Regional Blood Transfusion Centers of Morocco. This study involved 538 cases. The comparison of blood group frequencies between blood donors and patients with breast carcinoma shows that those with groups B and O are respectively the most (15.68% vs 25.8%) and least (46.05% vs 38.3%) affected. Presence of positive correlations between blood type and different histological characteristics of breast tumors: SBR, estrogen receptors, HER2... Despite all the statistical evidence regarding the involvement of the ABO system in human physiology and pathophysiology, the mechanisms by which it may interact with cancer development and progression, are still poorly understood. The findings of this work open new research perspectives to be explored.

Keywords: ABO; Blood group; Breast cancer.