FORMULATION AND EVALUATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF CEFPODOXIME PROXETIL
Dr. Nilesh Mahadeo Khutle and *Divya Kelan
Liquid Self micro-emulsifying drug delivery system (L-SMEDDS) was developed with the objective to overcome the problems associated with oral delivery of Cefpodoxime proxetil (CFP), a poorly absorbable, high dose antibiotic having pH dependant solubility. Solubility of CFP in various oils was determined to select the key components of SMEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oily phase. The optimized L-SMEDDS formulation showed a globule size of 30nm. The optimised SMEDDS formulation showed complete release of CFP within 30 min. Neusilin US2 was used as adsorbing agent to convert optimised L-SMEDDS to Solid Self micro-emulsifying drug delivery system (S-SMEDDS), which were then filled in hard gelatine capsule and evaluated further. The S-SMEDDS showed comparable in vitro dissolution profile as of L-SMEDDS.
Keywords: Cefpodoxime proxetil (CFP), pH dependant solubility, S-SMEDDS.
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