EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

SERUM OSTEOGLYCIN ASSAY AS AN EARLY MARKER IN DIAGNOSIS OF DIABETIC NEPHROPATHY AND ITS CORRELATION WITH DIFFERENT CKD STAGES

*Dr. Narendra Pulukuri MBBS, Dr. Prasanna Kumar HR MBBS, M.D, FICP, Dr. Tejashree A. MBBS, M.D, Dr. Shasidhara KC MBBS, M.D, Dr. Srinath KM, MBBS, M.D. and Dr. Manthappa M. MBBS, M.D.

ABSTRACT

Context: Glomerular impairment is also evident in diabetic normoalbuminuric patients, which might progress to advanced stages of CKD. Studies on osteoglycin which is an SLRP suggested that it has a role in pathogenesis of Nephropathy and its level could be assessed as a viable marker for diagnosing and identifying progression of nephropathy. Aims: To Assess and correlate the relation between levels of serum osteoglycin as a potential novel biomarker in the early diagnosis of Diabetic Nephropathy and correlating it with different CKD stages. Settings and Design: Cross sectional observation study. Material and Methods: It was conducted on 120 eligible subjects, who are divided into control and diabetes groups, subjects in diabetes group are further divided into 3 groups based on urine microalbumin creatinine ratio as normoalbuminuric, microalbuminuric and microalbuminuric and they are further divided into 5 CKD stages based on their eGFR calculated by CKD EPI equation. Serum osteoglycin levels were estimated in all the groups using an ELISA kit. Statistical analysis used: Comparison among different diabetes and control group was done using ANOVA (Analysis of variants) followed by post hoc comparison, ROC curve, multivariate analysis. Results: Our study showed that Serum osteoglycin levels can detect microalbuminuria in diabetes group with a sensitivity of 83.78% and specificity of 86.67% and its levels were low in stage 1 CKD they increase up to stage 3b CKD and as the disease progresses, they are decreased in stage 4 and 5 CKD. Conclusion: Osteoglycin has the potential to be an early marker for screening diabetic patients who are at risk for developing nephropathy and might also be helpful in assessing the progression of nephropathy as the changes in its levels were evident in different CKD stages However, as studies on osteoglycin levels in diabetic nephropathy are limited understanding the exact mechanism requires further research to establish it as a novel biomarker.

Keywords: Osteoglycin, diabetic nephropathy, microalbuminuria, Chronic kidney disease, Biomarker, SLRP-small leucine rich peptide.


[Full Text Article] [Download Certificate]

Citation

  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44

INDEXING

NEWS & UPDATION

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • EJPMR: FEBRUARY ISSUE PUBLISHED

    FEBRUARY 2024 issue has been successfully launched on 1 FEBRUARY 2024.

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 February 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia