STUDY ON ANTIMICROBIAL USE IN SURGICAL PROPHYLAXIS

Sriram A.*, Junior Sundresh N. and Dheepthi M.

ABSTRACT

Objectives: To observe and document the commonly used prophylaxis in this study. To observe and document the antimicrobials used to treat post-surgical infections. To observe the total consumption of antimicrobials used in the study using defined daily dose. Methods: This is cross-sectional study conducted in rajah muthaih medical college it is based on ASHP therapeutic guidelines for antimicrobial prophylaxis in surgery. Results: This result comprises 150 samples were admitted in surgery ward and investigated prospectively. Among that women were more in number with 54.67% than men with 45.33%. The majority of the patients were with an age group of 20-30 years (42.60%), 31-40 years (24%), 41-50 years (10%), 51-60 years (23.4%) were admitted in the surgery wards. In this study, the most commonly occurring surgery was appendicitis (60%), followed by inguinal hernia (13.3%), wound debridement (10%) hydrocele (6.7%), abscess left thumb (6.7%) and gastric perforation (2.7%) were mainly admitted for surgery. The most commonly used antimicrobial prophylaxis in this study was said to be Cefotaxime (58%) and ceftriaxone (27%) in this study. The antimicrobial agents which was prescribed to treat post-surgical infections in most of the cases was Gentamycin which was given to 32% of the cases followed by 22.7% patients were prescribed metronidazole, while 21.3% patients received Cefixime, a third generation cephalosporin and amikacin 16% were used along with the above antimicrobials. Conclusion: Third generation cephalosporins were considered as the most commonly used prophylaxis in this study. Gentamycin, metronidazole and Cefixime were used to treat post-surgical infections. Metronidazole, Cefixime and ciprofloxacin were frequently observed in surgical patients during hospital discharge. There is a need of hospital specific guidelines for antimicrobial use in choosing prophylaxis and proper counseling were needed for the patients in this study. Optimal timing of antibiotic administration is considered an important factor for effective prophylaxis.

Keywords: Antimicrobials, Prophylaxis, Surgical site infections.