EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

A CASE OF INTRA-EXTRADURAL CERVICAL SCHWANNOMA IN A CHILD WITH NEUROFIBROMATOSIS - TYPE 1

Dr. A. Susmitha, Dr. V. Anurekha, Dr. S. Amudhadevi, *Dr. K. S. Kumaravel, P. Sampathkumar, Dr. L. Sankar

ABSTRACT

Neurofibromatosis type 1 (NF1) is a rare autosomal dominant inherited disorder caused by mutation in NF-1 gene which is located in chromosome 17q11.2. Loss of the neurofibromin, the inactivator of protooncogen RAS, leads to an increase in incidence of tumors. Thus, patients are predisposed to have any central nervous system tumors, especially gliomas, which are the most common neoplasms in NF1. Spinal tumors are relatively rare. Meningiomas and Schwannomas are the two most common intradural extramedullary tumors associated with neurofibromatosis. Schwannoma is benign slow growing nerve sheath tumour. Schwanomas are mostly intradural extramedullary, and upper cervical in location. About 75% of schwannomas are intradural, 10% intra-extradural, and the rest 15% are extradural. We here report a 10-year-old boy with NF-1 presented with weakness of all four limbs and neck pain and was found to have MRI demonstrated intra-extradural mass, suggestive of schwannoma. Intraoperative findings found to be multi lobulated intradural extramedullary tumor extending with extradural component. The diagnosis of schwannoma was confirmed by Histo Pathological Examination which demonstrated Verocay bodies and with Immuno Histo Chemistry studies which demonstrated the presence of strong S-100 proteins. These are benign tumors and complete functional recovery can be obtained after complete excision.

Keywords: Meningiomas and Schwannomas.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia