DIFFERENCE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF SALMETEROL XINOFOATE IN BULK DRUG
Shembade S. H.*, Landage S. S. and Tamboli A. M.
In this research we aimed to develop a simple, precise, economical, accurate and selective method for estimation of Salmeterol xinofoate in bulk drug by using difference spectrophotometric method. Salmeterol xinofoate standard solution was scanned in the UV range (200-400nm) in a double beam UV Spectrophotometer. The spectrophotometric detection was carried out at an absorption maximum of 254nm by using Acetonitrile: Methanol (50:50) as a solvent. The accuracy, precision and other parameters of the method are determined and validated according to ICH guidelines. Thus the proposed method can be applied for estimation of Salmeterol xinofoate in pharmaceutical dosage form by difference spectrophotometric method.
Keywords: Salmeterol xinofoate, Double beam UV Spectrophotometer, Difference Spectrophotometric Method.
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