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European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Y. N. Spoorthy, P. Vijaya Kumar*, T. Sailaja Rani and L. K. Ravindranath


The reaction of ethyl 2-cyanoacetate with 2,5-dihydroxy-1,4-dithiane in presence of catalytic amount of tri ethyl amine in ethanol affords ethyl 3-aminothiophene-2- Carboxylate(3). The later on reaction with 3,4-dimethoxy benzaldehyde(4) in presence of few drops of acetic acid to form ethyl 3-((3,4-dimethoxybenzylidene)amino) thiophene-2-Carboxylate(5). Further the inter mediate(5) reacts with Monochloro acetyl chloride in presence of triethyl amine in dioxane forms ethyl 3-(3-chloro-2-(3,4-dimethoxy phenyl)-4-oxoazetidin-1-yl)thiophene-2- Carboxylate(6). Which on hydrolysis affords the ethyl 3-(3-chloro-2-(3,4-dihydroxyphenyl)-4-oxoazetidin-1-yl)thiophene-2-Carboxylate(7). A new series of ethyl 3-(3-chloro-2-(2-oxido-2-(4-substituted phenoxy)benzo[d]-dioxaphosphol-5-yl)-4-oxoazetidin-1-yl)thiophene-2-carboxylates (9a-g) were synthesized from ethyl 3-(3-chloro-2-(3,4-dihydroxyphenyl)-4-oxoazetidin-1-yl)thiophene-2-Carboxylate(7). by condensing with 4-substituted phenyl phosphoro dichloridates (8a-g). The structures of these analogues (9a-g) have been established by 1H NMR, IR, Mass spectral data and elemental analysis. This study describes the anti-microbial activity and docking studies of newly synthesized analogues (9a-g).

Keywords: Ethyl-2-cyanoacetate, 2,5-dihydroxy-1,4-dithiane, 3,4-dimethoxy benzaldehyde, Monochloro acetyl chloride, 4-substituted phenols , antimicrobial activity and docking studies.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia