( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Karthik G.* and Ravi Kumar Y. S.


Insulin resistance in DM is associated with reduced nitric oxide (NO) bioavailability and endothelial dysfunction.[1] Endothelial dysfunction due to reduced nitric oxide (NO) bioavailability is an earliest change and prominent feature of insulin resistance.[1,5,6,7] Deficiency of NO increases vascular resistance and promotes atherogenesis. L-Arginine is a common precursor for nitric oxide (NO), act as substrate for enzymes involved in nitric oxide synthases.[2,3] Asymmetric di methyl arginine (ADMA) which is a product of protein methylation on arginine is an endogenous competitive inhibitor of NO synthesis that exerts pro atherogenic effect. This study aim to correlate levels of serum Arginine and serum ADMA in DM with vascular complications and without vascular complications as compared with non diabetic subjects. This study concluded that Serum Arginine concentration is low among Diabetics as compared with Non diabetics and Arginine level was significantly low in subjects with vascular complications associated with diabetes mellitus as compared with Diabetics without vascular complications and Non diabetic subjects and also Serum arginine was inversely related to HbA1c. Serum ADMA level was high among Diabetics as compared with Non Diabetics and Serum ADMA levels were significantly high among diabetes with vascular complications as compared with diabetes without vascular complications and Non diabetic subjects and Serum ADMA levels were elevated in proportion to HbA1c. Hence it is suggestive that early supplementation of Arginine which is a precursor of NO, may retard progression of vascular complications associated with Diabetes mellitus.[8,9]

Keywords: ADMA: Asymmetric di methyl arginine, DM: Diabetes Mellitus.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia