SIMULTANEOUS ESTIMATION OF AMPROLIUM HYDROCHLORIDE AND SULFAQUINOXALIN SODIUM USING HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY

Athulya K.K.*, Sruthi K., Prasanth S.S., Panchami G.S. and Preethi P.R.

ABSTRACT

HPTLC was a method developed for the Simultaneous estimation of amprolium hydrochloride and sulfaquinoxalin sodium . The developed high performance thin layer chromatographic method was a suitable method for the analysis of drugs and here the calibration curve was plotted by using 2-10μg/ml of AMP.Hcl and 6-14μg/ml of SQS .Drugs shows good correlation coefficient and linearity. The Methods Shows good accuracy at a spiking levels of 80,100 and 120%. The developed methods can routinely be used for the estimation of amprolium hydrochloride and sulfaquinoxalin sodium in bulk and formulation.

Keywords: Amprolium hydrochloride, Sulfaquinoxalin sodium, HPTLC, chromatography, validation.